Design and Evaluation an Origanum majorana-Capped AgNPs Sensor: Determination of Trace Megestrol Drug in Urine and Blood Samples using Kinetic Spectrophotometric Method

Document Type : Research Paper

Authors

1 Department of Chemistry, Omidiyeh Branch, Islamic Azad University, Omidiyeh, Iran.

2 Department of Chemistry, Omidiyeh Branch, Islamic Azad University, Omidiyeh, Iran. Basic Science Department, Petroleum University of Technology, Ahvaz, Iran.

Abstract

Megestrol drug is a synthetic steroid progesterone, and it is used as an anti-plasma agent to treat advanced  breast  cancer  or  endometriosis. In  this  study,  for  determination  of  megestrol  drug  in solution using kinetic spectrophotometric method, we prepared a solution of Origanum majoranacapped AgNPs utilizing sodium borohydride as a stabilizer sensor. The calibration curve was linear in the range of (0.01 to 10.0 µg L−1). The standard deviation of (1.8%), and detection limit of the method (0.023 µg L−1 in time 8 min, 345 nm) were obtained for Sensor level response Origanum majorana-capped AgNPs with (95%) confidence evaluated. The observed outcomes confirmed the suitability recovery and a very low detection limit for measuring the megestrol drug. The method introduced to measure megestrol drug in real samples such as urine and blood was used and can be used for other drugs and hospital samples. 

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