Synthesis and Molecular Docking studies of Some Tetrahydroimidazo[1,2-a] pyridine Derivatives as Potent α-Glucosidase Inhibitors

Document Type : Research Paper

Authors

1 Department of Chemistry, Khuzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran. Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

2 Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. Chemistry and Chemical Engineering Research Center of Iran (CCERCI), 14335-186, Tehran, Iran.

3 Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

4 Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran

Abstract

KAl(SO4)2.12H2O is found to efficiently and heterogeneously catalyze the one-pot three-component reaction of 2-(nitromethylene)imidazolidine, malononitrile and aldehydes under mild conditions to afford the corresponding tetrahydroimidazo[1,2-a]pyridine in good yields and short reaction times.
Docking  study  of  some  compounds  in  the  active  site  of  α-glucosidase demonstrated  that  these compounds interacted with important active site residues with low binding energy in comparison to standard inhibitor acarbose.

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