One-pot Synthesis of Amidoalkyl Naphthol Derivatives as Potential Nucleoside Antibiotics and HIV Protease Inhibitors using Nano-SnO2 as an Efficient Catalyst

Document Type : Research Paper


Department of Chemistry, Payame Noor University, Iran


An  efficient  three-component  one-pot  synthesis  of 1-amidoalkyl-2-naphthols  from  2-naphthol, aldehydes, and acetamide using nano-SnO2as catalyst is described. The reactions were carried out at 80oC under water-solvent media. The structures of the compounds were characterized by IR, 1HNMR, 13C-NMR,  and  Mass  spectra  and  by  elemental  analysis.  The  advantages  of  the  effective method  were  good  yields,  short  reaction  times,  simple  work-up,  eco-friendly  solvent,  and inexpensive and reusable catalyst. The catalyst could be recycled and reused for five times without
much loss in its activity.