Document Type: Research Paper
Department of Applied Chemistry, Faculty of Science, Islamic Azad University, South Tehran Branch, Tehran, Iran.
Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.
An efficient and sustainable method was developed for electrocatalytic multicomponent synthesis of spirooxindole-chromene derivatives via a green one-pot, three component condensations of cyclic-1,3-diones, malononitrile and isatins inside an undivided cell where potassium bromide was applied as electrolyte in ethanol/DMSO (95/5 v/v) media, and a practical Fe-Mn-O composite was used as cathode electrode. The presented electrosynthesis approach proved to be reliable and cost-effective for the synthesis of target compounds in 83-91% yields. In this method, we highlight the utility of electrosynthesis method for the preparation of diverse spirooxindole-chromen
derivatives that can be a breakthrough for production of vital drugs.