Electrocatalytic Synthesis of Spirooxindole-Chromene Derivatives in Ethanol/DMSO Media using a Fe-Mn-O Composite as an Efficient Working Electrode

Document Type : Research Paper


1 Department of Applied Chemistry, Faculty of Science, Islamic Azad University, South Tehran Branch, Tehran, Iran.

2 Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.


An efficient and sustainable method was developed for electrocatalytic multicomponent synthesis of  spirooxindole-chromene  derivatives via  a  green  one-pot,  three  component  condensations  of cyclic-1,3-diones,   malononitrile  and   isatins   inside  an  undivided  cell  where  potassium  bromide was applied as electrolyte in ethanol/DMSO (95/5 v/v) media, and a practical Fe-Mn-O composite was used as cathode electrode. The presented electrosynthesis approach proved to be reliable and cost-effective for the synthesis of target compounds in 83-91% yields. In this method, we highlight the  utility  of  electrosynthesis  method  for  the  preparation  of  diverse  spirooxindole-chromen
derivatives that can be a breakthrough for production of vital drugs.