BF3-SiO2 Nanoparticles: An Efficient Catalyst for the Multi-Component Synthesis of 3-(α-aroylamido) 4-hydroxycoumarin Derivatives in Water

Document Type: Research Paper

Authors

1 Department of Chemistry, Khuzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

2 Department of Chemistry, Mahshahr Branch, Islamic Azad University, Mahshahr, Iran

3 Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

Abstract

A green and efficient one-pot three component reaction of 4-hydroxycoumarin or 1,3-dimethylbarbutyric acid, aryl glyoxals and amides (thioacetamide) has been developed in the presence of BF3- SiO2 nanoparticles in water. This method has several advantages such as high to excellent product yields in short reaction time, atom economy, environment friendly, reusable catalyst and no need for chromatographic separations.

Keywords