One-pot, Environmentally Benign Procedure for the Synthesis of tetrahydrotetrazolo[1,5-a]quinazolines Using [Bmim]Cl/AlCl3 as a Task-specific Ionic Liquid

Document Type: Research Paper


Department of New Materials, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran


A practical and green approach for the one-pot multicomponent synthesis of fused tetrazolo[1,5-a]quinazoline derivatives has been described via the condensation of 5- aminotetrazole, dimedone, and various aldehydes using 1-butyl-3-methylimidazolium tetrachloroaluminate [bmim]Cl/AlCl3, as a catalyst and task-specific ionic liquid medium. The catalyst was showed remarkable advantages in comparison with previous methods. Short synthetic route, operational simplicity, high-to-excellent yields, eco-friendliness and mild reaction conditions are the advantages of this method.