Antimicrobial Modified-Tragacanth Gum/Acrylic Acid Hydrogels for the Controlled Release of Quercetin

Document Type: Research Paper

Authors

1 Department of Chemistry, Islamic Azad University, Masjed-Soleiman Branch, Masjed-Soleiman, Iran

2 Department of Chemistry, Islamic Azad University, Masjed-Soleiman Branch, Masjed-Soleiman, Iran Department of Chemical engineering, University of Naples Federico II, Naples, Italy

Abstract

In this study, new antimicrobial hydrogels were prepared via reaction of functionalized-tragacanth
gum (TG) biopolymer by quaternary ammonium functionalization of TG (QTG) with acrylic acid
(AA). Characterization of the QTG hydrogels (QTG-AA) was carried out by FTIR,
thermogravimetric analysis (TGA), and 1H NMR. Dynamic mechanical analysis, (DMA) was
conducted to characterize the mechanical behavior of hydrogels. Swelling behavior of the QTG
hydrogels exhibited dependence on the pH, immersion time, medium, and temperature. Loading and
in-vitro drug release from the final hydrogels were studied by using quercetin as a model drug. The
results exhibited the pH-sensitivity of the hydrogels for drug delivery. The antimicrobial effect of
the prepared hydrogels was investigated against some standard microorganisms and the results
demonstrated that the hydrogels possess good antimicrobial activity against gram-positive and
gram-negative bacteria as well as a fungus.

Keywords