Solvent-free Biginelli Reaction Catalyzed to Synthesis of Biologically Active 3,4-dihydropyrimidin-2-(1H) –ones/thiones Derivatives

Document Type: Research Paper


Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran


A convenient and highly efficient procedure for the synthesis of 3,4-dihydropyrimidin-2-(1H)-
one/thione derivatives via one-pot three-component Biginelli condensation of aryl
aldehydes,urea/thiourea and ethyl/methyl acetoacetate in the presence of Zn(SO4)2.7H2Oas an
efficient, readily and inexpensive catalyst under solvent-free conditions have been studied. This
protocol has advantages such as readily available and non-toxic catalyst, short reaction times, good
to high yields, solvent-free conditions, facile reaction profiles, high atom-economy and simple