Application of 2-methylpyridinum p-toluenesulfonate ([2-MPy][p-TSA]) as an efficient catalyst for the one-pot synthesis of hexahydroquinolines-3-carboxamides

Document Type: Research Paper

Authors

Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran

Abstract

2-Methylpyridinum p-toluenesulfonate ([2-MPy][p-TSA]) as a novel room temperature ionic liquid
was synthesized and evaluated as a recoverable catalyst for the one-pot synthesis of
hexahydroquinoline-3-carboxamide derivatives by four-component reaction of arylaldehydes,
dimedone, acetoacetanilide and ammonium acetate in high to excellent yield in ethanol at 50 oC.
The [2-MPy][p-TSA] catalyst was characterized via FT-IR, 1H NMR and 13C NMR spectroscopy.
An environmentally benign procedure, four-component in one pot reaction, high yields and simple
preparation of the catalyst are some advantages of this work.

Keywords