Voltammetric Determination of Venlafaxine by Using Multiwalled Carbon Nanotube- Ionic Liquid Composite Electrode


1 Department of Chemistry, Kazerun Branch, Islamic Azad University, Kazerun, Iran

2 Department of Chemistry, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran


The combination of multi-walled carbon nanotubes and ionic liquid 1-octylpyridinium hexa
flourophosphate (OPFP) yields a carbon nanocomposite (MWCNT-CILE) that can be well used as
electrode for electrocatalytic oxidation of venlafaxine (VEN). The influence of various
experimental parameters including pH of the solution, the amount of multi-walled carbon nanotube
used for the modification of the carbon ionic liquid electrode (CILE), accumulation potential,
accumulation time and scan rate on the voltammetric responses of venlafaxine were all investigated
in the present research. The oxidation peak potential of venlafaxine appeared at 640 mV at the
proposed electrode that is about 150 mV lower than the peak potential at traditional carbon paste
electrodes (CPE). The oxidation is irreversible and exhibits adsorption controlled behavior. Under
the optimum conditions, the anodic peak current has a linear relationship with venlafexine
concentration in the range of 10.0 to 500.0μM. The detection limit (three times signal-to-noise
ratio) of 0.47μM was found. Finally, the proposed sensor has the features of being sensitive,
reproducible, easily renewable and cost effective which might suggest promising applications for
determination of VEN in pharmaceiutical formualations as well as blood serum and urine samples.