Nano SnCl2-SiO2 Catalyzed Facile Synthesis of Aryloylamido Coumarins Derivatives

Document Type: Research Paper


Department of Chemistry, Mahshahr Branch, Islamic Azad University, Mahshahr, Iran


A highly efficient and general method for the synthesis of aryloylamido coumarins
derivatives by a three-component condensation of 4-hydroxycoumarin or 4-hydroxy-6-
methylpyran-1-one, aryl glyoxals and benzamide in the presence of nano silica supported tin
(II) chloride as a heterogeneous catalyst is established. In this method, SnCl2/nano SiO2 was
used as green and reusable catalyst. Excellent yields, short reaction times, simple workup,
and inexpensiveness and commercially availability of the catalyst are the advantages of this