Sodium Bismuthate: An Efficient Catalyst for the One-pot Synthesis of Biologically Active Spiro[4H-pyran] Derivativesunder Solvent-free Conditions

Authors

1 Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan,Iran

2 Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

Abstract

An efficient sodium bismuthate (NaBiO3) synthesis of biologically active spiro[4H-pyran]
derivatives has been accomplished via one-pot three-condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1,3-dicrbonyl compounds, α-naphthol and 4-hydroxycumarin under solvent-free conditions. The notable advantages of the present procedure are: eco-friendly, environmentally benign nature,low-cost and non-toxic catalyst, simplicity of operation with no necessity of chromatographic
purification steps, short reaction times, good to high yields and solvent-free conditions.

Keywords