Coupling of Amines, Dialkyl acetylenedicarboxylaes and Formaldehyde Promoted by Copper (II) Chloride: An Efficient Synthesis of Polysubstituted Dihydro-2-oxopyrrols


Faculty of Science, Velayat University, Iranshahr, Iran


An environmental friendly synthetic route for copper (II) chloride dihydrate catalyzed one-pot multicomponent
synthesis of biologically active high substituted dihydro-2-oxypyrroles has developed. The non-toxic, low-cost catalyst and eco-friendly and good to high yields are the notable benefits for the efficient synthesis of these products.