Three-component Process for the Synthesis of Some Thiophene Derivatives Using Water as a Green Media


Department of Chemistry, Gorgan Branch, Islamic Azad University, Gorgan, Iran.


A convenient and efficient three-component reaction to a one-pot synthesis of thiophene derivatives from activated acetylenic compounds and ethyl 2chloroacetoacetate in the presence of tetramethyl thiourea in water lead to the formation of thiophenes in good yields.