Modification of Polyvinyl Alcohol via Atom Transfer Radical Polymerization for Targeted Drug Delivery Applications

Document Type: Research Paper

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Abstract

In current study,a hydrogel based on biocompatible polymerwas prepared. The functionalization of polyvinyl alcohol (PVA)with epichlorohydrin(ECH) to produce epichlorohydrin-g-polyvinyl alcohol (PVA/ECH) as a suitable macroinitiator for atom transfer radical polymerization (ATRP) reaction was investigated.ThenN-vinyl pyrrolidone (NVP) waspolymerized on the surface of macroinitiatorin presence of CuCl as a catalyst and Pentamethyldiethylenetriamine (PMDETA) as aligand using ATRP to produce PNVP-g-PVA. The synthesized copolymer was characterized by Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Also equilibrium swelling was studied in distilled water and indicated the sustained expansion of them. At last, loading capacity and release profiles of ceftriaxone as a model drug from the hydrogel were determined by UV– Vis absorption measurement at λmax= 243 nm. In vitro drug release behavior was investigated in three different media (HCl solution: pH=3 and bicarbonate buffer solutions: pH=7 and pH=8).

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