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Journal of Applied Chemical Research
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Zare, A., Maghsoudi, M., Gholami, B., Moosavi-Zare, A. (2016). A Highly Efficient Protocol for the Synthesis of 2-Amidoalkylphenols using SO3H-Functionalized Phthalimide (SFP) under Solvent-free Conditions. Journal of Applied Chemical Research, 10(3), 31-39.
Abdolkarim Zare; Maryam Maghsoudi; Bentolhoda Gholami; Ahmad Reza Moosavi-Zare. "A Highly Efficient Protocol for the Synthesis of 2-Amidoalkylphenols using SO3H-Functionalized Phthalimide (SFP) under Solvent-free Conditions". Journal of Applied Chemical Research, 10, 3, 2016, 31-39.
Zare, A., Maghsoudi, M., Gholami, B., Moosavi-Zare, A. (2016). 'A Highly Efficient Protocol for the Synthesis of 2-Amidoalkylphenols using SO3H-Functionalized Phthalimide (SFP) under Solvent-free Conditions', Journal of Applied Chemical Research, 10(3), pp. 31-39.
Zare, A., Maghsoudi, M., Gholami, B., Moosavi-Zare, A. A Highly Efficient Protocol for the Synthesis of 2-Amidoalkylphenols using SO3H-Functionalized Phthalimide (SFP) under Solvent-free Conditions. Journal of Applied Chemical Research, 2016; 10(3): 31-39.

A Highly Efficient Protocol for the Synthesis of 2-Amidoalkylphenols using SO3H-Functionalized Phthalimide (SFP) under Solvent-free Conditions

Article 4, Volume 10, Issue 3, Summer 2016, Page 31-39  XML PDF (490.35 K)
Document Type: Research Paper
Authors
Abdolkarim Zare email ; Maryam Maghsoudi; Bentolhoda Gholami; Ahmad Reza Moosavi-Zare
Abstract
A highly efficient and simple protocol for the synthesis of 2-amidoalkylphenols has been described. The one-pot multi-component condensation of phenols with aromatic aldehydes and amides in the presence of catalytic amount of SO3H-functionalized phthalimide (SFP) under solvent-free conditions afford the title compounds in high yields and relatively short reaction times. It is noteworthy that the reaction between phenols, arylaldehydes and amides has been scarcely studied in the literature (in spite of the condensation of 2-naphthol with arylaldehydes and amides, which has been extensively reported).
Keywords
2-Amidoalkylphenol; phenol; Arylaldehyde; Amide; SO3H-functionalized phthalimide (SFP); Solid acid
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