Voltammetric Investigation of Thioridazine Using a Carbon Nanocomposite Electrode in Human Biological Samples

Document Type: Research Paper

Authors

Abstract

An electrochemical method employing a carbon nanocomposite electrode was developed to
measure thioridazine. The electrode has been designed by incorporation of montmorillonite
nanoclay into the carbon ionic liquid electrode. Surface morphology of the electrodes was
done using scanning electron microscopy. Adsorptive stripping voltammetry was applied
as a very sensitive analytical method for the determination of sub-micromolar amounts of
thioridazine. The optimized linear working range and detection limit (S/N=3) are 0.1-50 μM
and 21nM, respectively. The nanocomposite electrode demonstrates several advantages such
as simple preparation method, excellent activity in physiological conditions, low detection
limit, long-term stability, and remarkable voltammetric reproducibility. As a result, it can find
promising applications in blood serum and urine samples. 

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