Application of N-methylimidazole for the Synthesis of Dimethyl-{3-methyl-2-[(alkoxycarbonyl) anilino]-2,3-dihydro-1H-imidazol-1-yl)}-2-butenedioate Derivatives

Document Type: Research Paper

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Abstract

A one-pot synthesis ofdimethyl-{3-methyl-2-[(alkoxycarbonyl) anilino]-2,3-dihydro-1Himidazol-1-yl)}-2-butenedioatesanddimethyl-2-[(alkoxycarbonyl)anilino]-2-butenedioates derivatives via reactions between dimethyl acetylenedicarboxylate,1-methylimidazoleand N-phenylcarbamates is described. The mild reaction condition, simple mixing of the starting materials and good yields exhibit the synthetic advantage of this method.

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