SiO2-BaCl2 as a Highly Efficient and Reusable Heterogeneous Catalyst for the One-pot Synthesis of 3,4-dihydropyrimidin-2-(1H)- one/thione Derivatives Under Solvent-free Conditions

Document Type: Research Paper



An efficient protocol for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives
via multi-component coupling reaction of aromatic aldehydes, β-ketoester and urea or
thiourea under solvent-free conditions using Silica Supported Barium Chloride as a catalyst
is described. All prepared compounds with melting points, IR,1H NMR and 13C NMR were
identified. High yields, mild conditions, easy availability and reusability were some advantages
of this catalyst.