An Efficient Synthesis of Benzylamino Coumarin Derivatives via Three-component Coupling of 4-hydroxycoumarin, Aromatic Aldehyde and Cyclic Secondary Amine Catalyzed by CuO Nanoparticles

Document Type: Research Paper



A green and efficient one-pot synthesis of benzylamino coumarin derivatives was conducted
by a three-component condensation of 4-hydroxycoumarin, cyclic secondary amine, and
aromatic aldehyde in the presence of CuO nanoparticles (NPs) as a heterogeneous catalyst in
water at room temperature.