Water as the Green Media for the Synthesis of Isoquinoline Derivatives

Document Type: Research Paper

Authors

Abstract

An efficient synthesis of isoquinoline-2,3-dicarboxylates is described via one-pot reactions of
isoquinoline and alkyl bromids with dialkyl acetylenedicarboxylates in water at 70oC. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods. 

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